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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Animal cells bioreactors principles and optimal operations

Animal cells culture processes

ONLINE COURSE: On-demand

COURSE FEE: 350 € per session 

COURSE ORGANIZATION

Course organized in 4 sessions

Sessions scheduling: at your pace

Effort: 3 - 6 hours per session

COURSE DESCRIPTION

.The course provides an introduction to the concepts and methodologies employed by bioprocess engineers in the design and scale-up of animal cells bioreactors.

You will gain a basic understanding of key phenomena influencing cell cultures. And you will learn how to operate bioreactors to efficiently produce biopharmaceuticals, such as cells, proteins, and viruses.​

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INSTRUCTOR​

  • Jean-Marc ENGASSER, BioProcess Digital

DIGITAL LEARNING​

  • Learning platform with course resources

  • Recorded slideshow videos 

  • Spreadsheet exercises and bioreactors simulators

  • Online collective or one-to-one tutoring

COURSE PROGRAM

Part 1: Bioreactors influencing biochemical and physical phenomena

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SESSION 1: ​ANIMAL CELL CULTURES KINETICS

Rates of cells growth and death, substrates consumption, metabolites production

​Rates dependences on medium composition

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SESSION 2: ​OXYGEN AND CARBON DIOXIDE SOLUBILITIES AND TRANSFER RATES

Solubilities of oxygen and carbon dioxide in media

Transfer rates of oxygen and carbon dioxide between air and medium

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Part 2: Optimal cell culture bioreactors operations

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SESSION 3: ​BIOREACTOR BATCH AND FED-BATCH OPERATIONS

Batch operation: optimization of substrates concentrations and induction time

Fed-batch operation under substrates limitations: optimization of medium feeding 

 

SESSION 4: ​BIOREACTOR PERFUSION OPERATIONS

Perfusion reactors with suspended and adherent cells

Optimal perfusion operation for thigh cell densities and reactor productivities​

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The two parts can be taken independently 

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