BioProcess Digital Courses
BioProcess Digital Courses
BioProcess Digital Courses
BioProcess Digital Courses
BIOPROCESS DIGITAL PROFESSIONAL COURSES
BIOPROCESS DIGITAL PROFESSIONAL COURSES
Animal cells bioreactors principles and optimal operations
Animal cells culture processes
ONLINE COURSE: On-demand
COURSE FEE: 350 € per session
COURSE ORGANIZATION
Course organized in 4 sessions
Sessions scheduling: at your pace
Effort: 3 - 6 hours per session
COURSE DESCRIPTION
.The course provides an introduction to the concepts and methodologies employed by bioprocess engineers in the design and scale-up of animal cells bioreactors.
You will gain a basic understanding of key phenomena influencing cell cultures. And you will learn how to operate bioreactors to efficiently produce biopharmaceuticals, such as cells, proteins, and viruses.
INSTRUCTOR
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Jean-Marc ENGASSER, BioProcess Digital
DIGITAL LEARNING
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Learning platform with course resources
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Recorded slideshow videos
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Spreadsheet exercises and bioreactors simulators
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Online collective or one-to-one tutoring
COURSE PROGRAM
Part 1: Bioreactors influencing biochemical and physical phenomena
SESSION 1: ANIMAL CELL CULTURES KINETICS
Rates of cells growth and death, substrates consumption, metabolites production
Rates dependences on medium composition
SESSION 2: OXYGEN AND CARBON DIOXIDE SOLUBILITIES AND TRANSFER RATES
Solubilities of oxygen and carbon dioxide in media
Transfer rates of oxygen and carbon dioxide between air and medium
Part 2: Optimal cell culture bioreactors operations
SESSION 3: BIOREACTOR BATCH AND FED-BATCH OPERATIONS
Batch operation: optimization of substrates concentrations and induction time
Fed-batch operation under substrates limitations: optimization of medium feeding
SESSION 4: BIOREACTOR PERFUSION OPERATIONS
Perfusion reactors with suspended and adherent cells
Optimal perfusion operation for thigh cell densities and reactor productivities
The two parts can be taken independently