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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Introduction to microbial fermentation processes

Industrial fermentation processes. Fermentors technologies and scale-up. Batch, continuous, fed-batch and perfusion operations. Fermentations costs

ONLINE COURSE

On-demand

COURSE FEE

350 € per session

COURSE ORGANIZATION

Course organized in 8 sessions

   Sessions can be taken individually

Sessions scheduling: suggested one session per week

Effort: 4 - 6 hours per session

COURSE DESCRIPTION

The course provides a comprehensive overview of industrial fermentation processes, including their technologies, operations, scale-up, and cost analysis. It introduces the kinetics of microbial transformations and of oxygen transfer. It compared the fermentations batch, continuous, fed-batch, and perfusion operations. 

The course features a combination of methodological presentations, fermentation case studies, and quizzes.

INSTRUCTORS

  • Jean-Marc Engasser, BioProcess Digital

DIGITAL LEARNING

  • Learning platform with course resources

  • Live or recorded slideshow presentations

  • Case studies on spreadsheet templates with guides and corrections

  • Online quizzes

  • Online collective or one-to-one tutoring

COURSE PROGRAM

SESSION 1: INDUSTRIAL FERMENTATION PROCESSES

Microorganisms, media, products. Upstream and downstream operations. Fermentors technologies and operations

SESSION 2MICROBIAL KINETICS

KInetic analysis in batch and continuous fermentors. Microbial kinetic laws

SESSION 3FERMENTORS AERATION AND OXYGEN TRANSFER

Fermentors aeration technologies. Oxygen solubility and transfer kinetics. Determination of oxygen transfer coefficient 

SESSION 4: FERMENTATIONS SIMULATION, SCALE-UP, AND COST OPTIMIZATION 

Fermentations influencing phenomena and simulation models. Fermentors scale-up. Cost evaluation and optimization

SESSION 5: BATCH FERMENTATIONS

Batch fermentations principles, kinetics, productivity limitations, and operational optimization

SESSION 6: CONTINUOUS FERMENTATIONS 

Continuous fermentations principles, kinetics, productivity limitations, and operational optimization

SESSION 7: FED-BATCH FERMENTATIONS

Fed-batch fermentations principles, kinetics, productivity limitations, and operational optimization

SESSION 8: PERFUSION HIGH-DENSITY FERMENTATIONS 

Perfusion fermentations principles and technologies, kinetics, productivity limitations, and operational optimization

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