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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Introduction to microbial fermentation processes

Industrial fermentation processes. Microbial kinetics. Oxygen and CO2 in fermentors. Optimal operation of batch, continuous and fed-batch fermentations 

ONLINE COURSE

On-demand

COURSE FEE

350 € per session

COURSE ORGANIZATION

Course organized in 7 sessions

   Sessions can be taken individually

Sessions scheduling: suggested one session per week

Effort: 4 - 8 hours per session

COURSE DESCRIPTION

The course provides a comprehensive overview of industrial fermentation processes, including their technologies, operations, scale-up, and cost optimization. It reviews the kinetics of microbial transformations, the solubilities and transfer kinetics of oxygen and CO2. It provides in-depth insights into the optimal operations of batch, continuous, fed-batch, and high cell-density fermentations. 

The course features a combination of methodological presentations and fermentation case studies.

INSTRUCTOR​

  • Jean-Marc Engasser, BioProcess Digital

DIGITAL LEARNING​

  • Learning platform with course resources

  • Live or recorded slideshow presentations

  • Case studies on spreadsheet templates with guides and corrections

  • Online quizzes

  • Online collective or one-to-one tutoring

COURSE PROGRAM

SESSION 1: INDUSTRIAL FERMENTATION PROCESSES

Microorganisms, media, products. Process operations. Fermentors technologies and operations. Fermentation costs

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SESSION 2: MICROBIAL KINETICS

KInetic analysis in batch and continuous fermentors. Microbial kinetic laws. Industrial fermentations kinetics

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SESSION 3: OXYGEN AND CO2 IN FERMENTORS

Fermentors aeration technologies. Solubilities and transfer kinetics. Determination of oxygen transfer coefficient 

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SESSION 4: BATCH FERMENTATIONS OPTIMAL OPERATIONS

Batch fermentations principles, kinetics and productivities. Optimization of anaerobic and aerobic fermentations

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SESSION 5: CONTINUOUS FERMENTATIONS OPTIMAL OPERATIONS 

Continuous fermentations principles. Dynamic and steady-state kinetics. Optimization of anaerobic and aerobic fermentations

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SESSION 6: FED-BATCH FERMENTATIONS OPTIMAL OPERATIONS

Fed-batch fermentations principles, operation and  kinetics. Optimization of fermentations for biomass and metabolites

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SESSION 7: HIGH CELL-DENSITY FERMENTATIONS 

Intensification by oxygen-enriched air. Perfusion fermentations with cell recycling. Limitations of high-density fermentations

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