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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Design and cost evaluation of bioprocesses

Material balance, energy consumption, equipment sizing, investment and production cost, sensitivity and uncertainty analysis, cost reduction strategies

ONLINE COURSE: On-demand

COURSE FEE: 300 € per session 

COURSE ORGANIZATION

Course organized in 6 sessions

Scheduling: suggested one session per week

Effort: 4 - 8 hours per session

COURSE DESCRIPTION

The course teaches he basic methodology for the design and cost evaluation of bioprocess involving biotransformations, separation and thermal unit operations.

The guiding thread of the course is a virtual R&D project on the design and cost evaluation of an enzyme production process. The project objective is to design the most cost efficient process for the enzyme production by recombinant bacteria.

INSTRUCTOR​

  • Jean-Marc ENGASSER, BioProcess Digital

WHAT YOU'LL LEARN ​​

  • Evaluate the bioprocess materials consumption and effluents production, energy consumption and equipment sizes 

  • Determine the costs of materials, utilities, labor, equipment investment and utilization, and the overall bioprocess production cost 

  • Construct a spreadsheet simulator for bioprocess design and cost evaluation

  • Evaluate the uncertainty of the cost evaluation

  • Assess process modifications to reduce energy consumption and production cost

DIGITAL LEARNING​

  • Learning platform with course resources

  • Live or recorded slideshow videos

  • Fermentation project on spreadsheet templates with self-corrections and guides

  • Online collective or one-to-one tutoring

COURSE PROGRAM

SESSION 1: BIOPROCESS MATERIAL BALANCE 

Case study project: Enzyme production process by fermentation. Material balance of the process 

SESSION 2: BIOPROCESS ENERGY CONSUMPTION

Mechanical and thermal energies consumption of the process equipment

SESSION 3: EQUIPMENT SIZING

Sizing of the process equipment: tanks, fermentors, sterilizer, centrifuge, ultrafilter, spraydryer

​​

SESSION 4: INVESTMENT AND PRODUCTION COST

Investment cost of the production plant. Enzyme production cost: materials, energy, labor, equipment utilization

SESSION 5: SENSITIVITY AND UNCERTAINTY ANALYSIS

Cost sensitivity analysis. Uncertainty of enzyme production cost

SESSION 6: BIOPROCESS COST OPTIMIZATION

Bioprocess design modifications for energy saving and production cost reduction

Capture d’écran 2020-05-24 à 19.23.40 co
Nancy, France
© 2025 BioProcess Digital, Inc
Online courses
Introduction to bioprocess design, scale-up and simulation
Bioprocess engineering basic principles
Introduction to microbial fermentation engineering
Digital scale-up and optimization of microbial fermentations
Case study in Digital scale-up and optimization of fermentation processes
Introduction to enzymatic bioconversion processes
Simulation, scale-up, and optimization of soluble and immobilized enzyme 
bioreactors
Introduction to animal cells culture processes
Simulation, scale-up, and optimal operation of suspended and adherent animal cells bioreactors
Design, scale-up, and cost evaluation of recombinant proteins production

Bioprocess design and cost evaluation
Introduction to bioprocess Life Cycle Assessment
Life Cycle Assessment of bioprocesses and byproducts
 
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