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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Simulation, scale-up and optimal operation of microbial fermentors

Microbial fermentation processes

ONLINE COURSE

On-demand

  

COURSE FEE

300 € per session 

  

COURSE ORGANIZATION

Course organized in 8 sessions

Sessions scheduling: suggested one seesion per week

Effort: 4 - 8 hours per session

  

COURSE DESCRIPTION

The course teaches the kinetic analysis, the modeling-simulation, the scale-up and the optimal operation of fermentation processes.

The guiding thread of the course is a virtual R&D project on the glutamic acid fermentation. The objective is to use most efficiently a bacterial strain in an industrial 200 m3 fermentor, in order to reach the highest annual glutamate production

  

INSTRUCTOR​

  • Jean-Marc ENGASSER, BioProcess Digital

  

WHAT YOU'LL LEARN ?​

  • Design and analyze experiments to determine the kinetics of microbial reaction and oxygen transfer

  • Construct fermentors simulation models 

  • Use process simulators to scale up and optimize the microbial fermentor in batch and fed-batch modes for highest productivity 

  

DIGITAL LEARNING​

  • Learning platform with course resources

  • Live or recorded slideshow videos

  • Fermentation project on spreadsheet templates with self-corrections and guides

  • Online collective or one-to-one tutoring

  

COURSE PROGRAM

SESSION 1: KINETIC ANALYSIS OF THE FERMENTATION

At the laboratory, evaluation of the rates of bacteria growth, sugar consumption, and metabolites production

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SESSION 2: OXYGEN CONSUMPTION AND TRANSFER

At the laboratory, determination of the oxygen consumption rate, of the oxygen solubility and transfer rate 

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SESSION 3: FERMENTATION MODELING-SIMULATION

Modeling-simulation of the bacteria growth and metabolism in the laboratory batch fermentor

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SESSION 4: BATCH FERMENTATION SCALE-UP AND PRODUCTION OPTIMIZATION 

Scale-up of the fermentor simulation model. Optimization of the batch fermentation operation for highest production

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SESSION 5: BATCH FERMENTATION COST OPTIMIZATION 

Economic evaluation of the fermentation process. Optimization of the batch fermentation for lowest production cost

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SESSION 6: CONTINUOUS AND FED-BATCH FERMENTATIONS OPTIMIZATION

Optimization the continuous and fed-batch fermentations for reduced co-metabolites production and lowest cost

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SESSION 7: FERMENTATION INTENSIFICATION BY OXYGEN-ENRICHED AIR

Optimization of the fed-batch fermentor, aerated with oxygen-enriched air, for increased production

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SESSION 8: FERMENTATION INTENSIFICATION BY PERFUSION OPERATION

Optimization of the micro-filtration membrane fermentor, for increased production under perfusion operation

  

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