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BIOPROCESS DIGITAL PROFESSIONAL COURSES
Scientific basis of bioprocess design and simulation

Bioprocess engineering basic principles

Material and energy balances, fluid flow and residence time distribution, mass and heat transfer, enzymatic and cellular kinetics 

Online course: On-demand

Course fee: 400 € per session

Course content

8 sessions: sessions can be taken separately

Sessions scheduling: suggested one seesion per week

Effort: 4 - 8 hours per session

COURSE DESCRIPTION

The course provides a comprehensive overview of the scientific basis of bioprocess engineering. It covers the essential concepts and methods for bioprocess simulation, scale-up, and design.

The course offers a combination of methodological presentations, exercises, case study problems and projects.

INSTRUCTOR​

  • Jean-Marc Engasser, BioProcess Digital

WHO SHOULD ATTEND?

The course is aimed at biologists, chemists, engineers, technicians and managers in the chemical, pharmaceutical, food and environmental industries. It is particularly relevant to anyone involved in the development and scale-up of enzymatic, microbial or animal cells bioprocesses.

DIGITAL LEARNING

  • Bioprocess Digital learning platform for courses resources 

  • Recorded slideshow videos         

  • Exercises and problems on spreadsheet templates with self corrections and guides

  • Online quizzes     

  • Online collective or one-to-one tutoring 

COURSE PROGRAM

SESSION 1: MATERIAL BALANCES

  • Initial-final and instantaneous mass balances. Principle of mass conservation

  • Use of material balances for kinetic analysis, simulation and sizing of bioreactors

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SESSION 2: ​ENERGY BALANCES

  • Initial-final and instantaneous energy balances. Mechanical energy and heat.

  • Use of energy balances for energy consumption evaluation and temperature simulation

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SESSION 3: FLUID FLOW IN BIOPROCESSES

  • Principle of momentum conservation and transfer. Newtonian fluids. Laminar and turbulent​ flow

  • Application to flows in pipes and tanks agitation. Evaluation of energy consumption

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SESSION 4: RESIDENCE TIME DISTRIBUTION

  • Residence time distribution (RTD) concept. Experimental RTD analysis and flow models

  • Influence of RTD on continuous bioreactor and sterilizer sizing

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​SESSION 5: MASS TRANSFER  

  • Mass transfer rate laws by diffusion and convection. Concept of mass transfer resistances

  • Kinetic analysis and simulation of solute diffusion in solids, and oxygen transfer in bioreactors

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SESSION 6: HEAT TRANSFER  

  • Heat transfer rate laws by conduction, convection, and radiation. Concept of heat transfer resistances

  • Evaluation of heat transfer fluxes and temperature profiles across solids

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SESSION 7: ENZYMATIC BIOCONVERSION KINETICS

  • Kinetic laws for enzymatic reactions and enzyme denaturation. Influence of temperature

  • Kinetic analysis and simulation of enzymatic bioconversions in bioreactors

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SESSION 8: MICROBIAL OR CELLULAR TRANSFORMATION KINETICS

  • Kinetic laws of cellular growth and death, substrates consumption, and metabolites production

  • Kinetic analysis and simulation of cellular transformations in bioreactors

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